High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation
نویسندگان
چکیده
منابع مشابه
HEARING IMPAIRMENT CAUSED BY WAR
120 cases of Iranian soldiers complaining of hearing loss, were studied over a period of three years at the Ghaem Medical Center in Mashad,Iran. There was adequate information in III cases that their engagement in different types of explosions had caused their hearing impairment. The following aspects were evaluated: 1- Categorization of their hearing impairment. 2- The otoscopic findings...
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The concurrent application of subtoxic doses of soluble oligomeric forms of human amyloid-beta (oAβ) and Tau (oTau) proteins impairs memory and its electrophysiological surrogate long-term potentiation (LTP), effects that may be mediated by intra-neuronal oligomers uptake. Intrigued by these findings, we investigated whether oAβ and oTau share a common mechanism when they impair memory and LTP ...
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Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in mediating many beneficial effects of resveratrol, such as reduction of inflammation and induction of cancer cell death. Although various resveratrol targets have been suggested, the molecule that mediates resveratrol-induced autophagy rema...
متن کاملMonepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway.
We have recently shown that the novel anthelmintic drug monepantel (MPL) inhibits growth, proliferation and colony formation, arrests the cell cycle and induces cleavage of PARP-1 in ovarian cancer cell lines. Here we report on the mechanism behind the anticancer properties of MPL. The cytotoxic effect of MPL on ovarian cancer cells (OVCAR-3 and A2780) was investigated employing a panel of test...
متن کاملhearing impairment caused by war
120 cases of iranian soldiers complaining of hearing loss, were studied over a period of three years at the ghaem medical center in mashad,iran. there was adequate information in iii cases that their engagement in different types of explosions had caused their hearing impairment. the following aspects were evaluated: 1- categorization of their hearing impairment. 2- the otoscopic findings. 3- t...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2019
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2019.09.049